Week 17 Pathology


Retinoblastoma – commonest eye cancer in kids

  • Retinoblastoma is the most common primary intraocular malignancy of children.
  • The molecular genetics of retinoblastoma indicate that the cell of origin is neuronal.
  • Approximately 40% of cases occur in patients who inherit a germline mutation of one RB allele.
  • Chemotherapy is often the first of treatment to attempt to reduce the tumour followed by laser treatment or cryopexy.
  • Spread is to the brain and bone marrow and seldom to the lungs.
  • Prognosis is poor if there is extra ocular extension and invasion along the optic nerve, and by choroidal invasion