- Functions by binding to the intracellular protein tubulin, therefore preventing its polymerization and reducing leukocyte migration and phagocytosis.
- It also inhibits the formation of LTB4.
- Therefore, indications as follows:
- Acute gout
- Acute Mediterranean fever
- May be effective in hepatic cirrhosis.
- Its main side effect is diarrhea.
- However, because it inhibits intracellular tubulin function, it can be quite toxic in overdoses. Acute OD will cause bloody diarrhea, shock and renal failure. Death is secondary to ascending CNS paralysis.
- IV colchicine is thought to have more side effects.