1. Dopamine (D2 receptor) antagonist)
    • Hence, used as a prokinetic
      1. Increased esophageal peristaltic amplitude
      2. Increased lower esophageal sphincter pressure
      3. Enhanced gastric emptying.
    • No effect on small intestine/colonic activity
  2. Indications
    • GORD
    • Pro-kinetic in ICU
    • Anti-emetic (due to central D2 receptor blockade)
  3. However, because of its D2 receptor blockade, it has CNS effects
    • Extra-pyramidal side effects
    • Tardive dyskinesia
    • Elevated prolactin levels will cause galactorrhea, impotence and gynecomastia.