- Binds to the 50S ribosomal subunit.
- Effective against Gram+ve bacteria and anaerobes (both Gram+ve and Gram-ve). It does not have activity against aerobic Gram-ve bacteria due to the presence of the cell wall.
- It is effective against staph, strep and pneumococci, but enterococcus is resistant to clindamycin.
- Therefore, indications for clindamycin are as follows:
- Skin infections
- Anaerobic infections
- May be used to treat GIT infections or PID.
- Note that resistance to clindamycin will confer cross resistance to macrolides. Resistance is due to:
- Mutation of ribosomal receptor site
- Modification of receptor site by methylase
- Enzymatic inactivation.