- Anti-fungal drug
- Interferes with cell membrane function by binding to ergosterol (The predominant sterol of fungi is ergosterol, which is a major component of the fungal lipid cell membrane)
- Therefore, it is the antifungal with the broadest spectrum of activity, including candida, Cryptococcus, aspergillus and histoplasma.
- It is useful for life-threatening mycotic infections, and is often used as an initiation agent.
- Toxicity can be divided into immediate and long term.
- Infusion related toxicity, i.e. fevers, chills, vomiting, headache, hypotension and muscle spasms.
- Treat by slowing down the infusion rate.
- Long term
- Renal failure (most significant reaction) which may be irreversible.
- Anaemia (secondary to renal damage)
- Abnormal LFTs.
- Intrathecal amphotericin is very toxic.