Neurotransmitter Chemistry of the Autonomic nervous system
- Colinergic Transmission
- Adrenergic Transmission
Pharmacology of the eye
|Aq secretion||increase out flow of aq humour–> lower intraocular pressure||Decreased production of aq humour –> decreased intraocular pressure??|
Direct-acting cholinergics (nicotinic / muscarinic).
- Ciliary muscle contraction
- Negative inotrope
- Slows conduction
- Increased secretion – GI, bronchial, salivary, sweat, lacrimal
- Increased GI motility
- Sphincters relaxed
- Detruser contraction
Indirect-acting cholinergics (i.e. Cholinesterase inhibitors).
- Alcohols (Edrophonium).
- Duration of action 5-15mins
- Carbamates (Neostigmine).
- Duration of action 0.5-2hrs
- Dry eyes
- Loss of accomodation(cycloplegia)
- Dry mouth
- Urinary retention
- Decreased sweating (can be increased if increased sympathetics)
- Tachycardia (brady at low dose, tachy at high dose)
- Bronchodilation and reduced bronchial secretion.
- Eye effects Lasts longer than other effects.
- What drugs affect the eye.
- Indirect cholinomimetics